BRCA Challenge

Publishes the largest public source for information on BRCA1 and BRCA2 genetic variants

The BRCA Challenge aims to advance our understanding of the genetic basis of breast cancer, ovarian cancer, and other diseases. It publishes the largest public source for information on BRCA1 and BRCA2 genetic variants, the BRCA Exchange. Pooling genetic and corresponding clinical data from around the world provides better information for patients and supports expert variant pathogenicity classifications made by the ENIGMA Consortium.

BRCA Challenge information
Driver Project Website
Location
International
Thematic Area
Champions
  • Melissa Cline
  • Amanda Spurdle
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BRCA Exchange

Information drawn from multiple databases — which have been intelligently merged together — provides researchers with a set of BRCA variations and annotations that is as comprehensive as possible.

Products Used
Workflow Execution Service (WES), Beacon, Variation Representation (VRS)